Three Causes of an Ovarian Failure



Premature ovarian failure (primary ovarian insufficiency) is a loss of normal function of your ovaries before age 40. In such a case, they don't produce normal amounts of the hormone estrogen or expel eggs as regularly as a reproductive system should. Gurls, since this leads to many infertility concerns, you must be aware of their causes: 





  • Chromosomal defects. Certain genetic disorders are associated with premature ovarian failure. These include mosaic Turner's syndrome — in which a woman has only one normal X chromosome and an altered second X chromosome — and fragile X syndrome — in which the X chromosomes are fragile and break.

  • Toxins. Chemotherapy and radiation therapy are the most common causes of toxin-induced ovarian failure. These therapies can damage the genetic material in cells. Other toxins such as cigarette smoke, chemicals, pesticides and viruses might hasten ovarian failure.

  • An immune system response to ovarian tissue (autoimmune disease). In this rare form, your immune system produces antibodies against your ovarian tissue, harming the egg-containing follicles and damaging the egg. What triggers the immune response is unclear, but exposure to a virus is one possibility.