Premature ovarian failure (primary ovarian insufficiency) is a loss of normal function of your ovaries before age 40. In such a case, they don't produce normal amounts of the hormone estrogen or expel eggs as regularly as a reproductive system should. Gurls, since this leads to many infertility concerns, you must be aware of their causes:
Chromosomal defects. Certain genetic disorders are associated with premature ovarian failure. These include mosaic Turner's syndrome — in which a woman has only one normal X chromosome and an altered second X chromosome — and fragile X syndrome — in which the X chromosomes are fragile and break.
Toxins. Chemotherapy and radiation therapy are the most common causes of toxin-induced ovarian failure. These therapies can damage the genetic material in cells. Other toxins such as cigarette smoke, chemicals, pesticides and viruses might hasten ovarian failure.
An immune system response to ovarian tissue (autoimmune disease). In this rare form, your immune system produces antibodies against your ovarian tissue, harming the egg-containing follicles and damaging the egg. What triggers the immune response is unclear, but exposure to a virus is one possibility.