Sakshi started her career in 2005 at a very young age of 19 years from a regional news channel Total TV. In 2008 Joshi joined the national channel India TV. Covering Jammu Terrorist encounters to Delhi Blasts, 2009 general elections to interviewing big names like Amitabh Bachchan, Katrina Kaif, Bobby Deol, Shahid Kapoor, Hritik Roshan, Gautam Gambhir, she made her mark in reporting and was soon selected to BBC world service as a producer. Although she worked with BBC radio and online for a small period but she did become one of the favourite voices of BBC radio presenting their morning and prime time shows Namaskar Bharat, Dinbhar and Tees Minute. In 2010, she moved to IBN7 Network 18, now called News18India as an anchor. After a sabbatical she joined News 24 (India) in February 2016 as an anchor cum special correspondent. She anchors a popular debate show called 5 ki Panchayat every day.